Mitochondrial transcription

Across TCGA cell cohorts, RNA activity of the Mitochondrial transcription pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UTP15, UTP25, and ANAPC5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UTP15 grouped by Mitochondrial transcription-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	UTP15 →	-0.686	-0.075	<.001	.001	3	4
BLOOD_Leukemia	UTP25 →	-0.186	-0.312	.005	.005	3	4
BLOOD_Leukemia	ANAPC5 →	+0.441	+0.291	<.001	.006	3	3
LUNG_NSCLC_LUSC	ZHX2 →	-0.216	-0.217	.001	.006	3	3
BLOOD_Leukemia	PSMD12 →	+0.372	+0.375	.005	<.001	3	3
URINARY_TRACT	GPNMB →	-0.266	-0.213	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UTP15 by Mitochondrial transcription activity — LIVER

Explore this box plot interactively →