Mitochondrial transcription

Across TCGA cell cohorts, RNA activity of the Mitochondrial transcription pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFYVE27, SH2D5, and DVL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial transcription activity versus ZFYVE27 in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZFYVE27 →	+0.770	+0.155	.002	.007	3	5
UPPER_AERODIGESTIVE_TRACT	SH2D5 →	+1.451	+0.128	.004	<.001	3	4
KIDNEY	DVL2 →	+1.018	+0.133	.003	.003	3	4
STOMACH	BAG6 →	+0.709	+0.188	.003	.004	2	5
PANCREAS	AGAP4 →	+1.348	+0.256	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ARID3B →	+0.858	+0.156	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006390 vs ZFYVE27 — PANCREAS

Explore this scatter interactively →