Transcription initiation at RNA polymerase III promoter

Across TCGA patient cohorts, RNA activity of the Transcription initiation at RNA polymerase III promoter pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT3, LRRFIP1, and GTF3C4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription initiation at RNA polymerase III promoter activity versus FERMT3 in GBM (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FERMT3 →	-0.532	-0.049	<.001	<.001	3	7
CCRCC	LRRFIP1 →	-0.297	-0.037	<.001	<.001	3	7
LSCC	GTF3C4 →	+0.261	+0.025	<.001	.005	3	7
GBM	PARVG →	-0.838	-0.051	<.001	.001	3	7
HNSC	HNRNPK →	+0.146	+0.050	<.001	.005	3	7
CCRCC	SAMSN1 →	-0.377	-0.037	.007	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006384 vs FERMT3 — GBM

Explore this scatter interactively →