Transcription initiation at RNA polymerase III promoter

Across TCGA cell cohorts, RNA activity of the Transcription initiation at RNA polymerase III promoter pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYCARD, NOP16, and SOD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PYCARD grouped by Transcription initiation at RNA polymerase III promoter-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PYCARD →	-1.976	-0.319	<.001	<.001	3	4
CNS	NOP16 →	-0.493	-0.274	.001	<.001	3	4
BREAST	SOD1 →	-0.737	-0.156	.002	.004	3	3
BREAST	DAZAP2 →	-0.608	-0.192	.002	.003	3	3
CNS	GIPR →	+1.265	+0.355	<.001	<.001	3	3
CNS	BNIP1 →	-0.391	-0.301	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PYCARD by Transcription initiation at RNA polymerase III promoter activity — CNS

Explore this box plot interactively →