Transcription initiation at RNA polymerase III promoter

Across TCGA cell cohorts, RNA activity of the Transcription initiation at RNA polymerase III promoter pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMCO3, FAM161A, and TWNK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription initiation at RNA polymerase III promoter activity versus TMCO3 in SKIN (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMCO3 →	-0.815	-1.210	.002	<.001	3	5
LIVER	FAM161A →	+1.159	+1.277	<.001	<.001	3	5
OVARY	TWNK →	+0.864	+0.979	.006	.005	3	5
STOMACH	RPL31 →	+0.908	+1.232	.005	.007	2	5
STOMACH	PCMT1 →	-1.224	-1.313	.001	<.001	3	4
STOMACH	SLC25A19 →	+0.860	+1.235	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006384 vs TMCO3 — SKIN

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