Transcription by RNA polymerase III

Across TCGA patient cohorts, RNA activity of the Transcription by RNA polymerase III pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZC3H12A, SSRP1, and STRBP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription by RNA polymerase III activity versus ZC3H12A in LSCC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZC3H12A →	-0.183	-0.034	.008	<.001	3	6
LSCC	SSRP1 →	+0.438	+0.051	<.001	<.001	3	5
HNSC	STRBP →	+0.416	+0.060	<.001	.003	3	5
LSCC	THOC5 →	+0.234	+0.043	.003	<.001	3	5
UCEC	UBASH3B →	-0.365	-0.049	.002	.001	3	5
OV	VPS13C_S737 →	-0.692	-0.033	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006383 vs ZC3H12A — LSCC

Explore this scatter interactively →