Transcription by RNA polymerase III

Across TCGA patient cohorts, RNA activity of the Transcription by RNA polymerase III pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B1, RFC3, and UTP6, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription by RNA polymerase III activity versus SF3B1 in BRCA (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SF3B1 →	+0.207	+0.607	<.001	<.001	3	10
GBM	RFC3 →	+0.375	+0.954	<.001	<.001	2	10
UCEC	UTP6 →	+0.298	+0.573	<.001	<.001	3	9
LSCC	DNMT1_S714 →	+0.751	+0.296	<.001	<.001	3	9
UCEC	MYBBP1A →	+0.383	+0.534	<.001	<.001	3	9
LSCC	NOC2L →	+0.298	+0.216	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006383 vs SF3B1 — BRCA

Explore this scatter interactively →