Transcription by RNA polymerase III

Across TCGA cell cohorts, RNA activity of the Transcription by RNA polymerase III pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP2K7, SF3A2, and KRI1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription by RNA polymerase III activity versus MAP2K7 in LARGE_INTESTINE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAP2K7 →	+0.528	+0.890	<.001	<.001	3	6
LARGE_INTESTINE	SF3A2 →	+0.483	+0.956	.003	.003	2	5
BREAST	KRI1 →	+0.850	+1.193	<.001	.002	3	4
BREAST	RNF8 →	+0.662	+1.092	<.001	<.001	3	4
BONE	DLK2 →	+1.157	+1.096	.004	.003	3	4
BONE	RPL12 →	+0.903	+1.344	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006383 vs MAP2K7 — LARGE_INTESTINE

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