Adenosine to inosine editing

Across TCGA patient cohorts, RNA activity of the Adenosine to inosine editing pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ELAPOR1, ATP1B1, and GSR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenosine to inosine editing activity versus ELAPOR1 in BRCA (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ELAPOR1 →	-0.726	-0.049	<.001	<.001	3	6
GBM	ATP1B1 →	-0.605	-0.072	<.001	<.001	3	6
LSCC	GSR →	-0.438	-0.066	.006	.002	3	6
UCEC	CBX3_S176 →	+0.362	+0.062	.001	<.001	3	6
CCRCC	PPIL4 →	+0.143	+0.046	.002	.004	3	6
LSCC	AP1S1 →	-0.211	-0.066	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006382 vs ELAPOR1 — BRCA

Explore this scatter interactively →