Adenosine to inosine editing

Across TCGA cell cohorts, RNA activity of the Adenosine to inosine editing pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF2KMT, PMS1, and KIAA0586, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EEF2KMT grouped by Adenosine to inosine editing-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EEF2KMT →	-0.849	-1.187	.001	.004	3	3
SKIN	PMS1 →	-0.482	-1.114	.005	.003	3	3
CNS	KIAA0586 →	-0.594	-0.902	<.001	.001	3	3
CNS	CINP →	-0.445	-0.793	.003	.004	3	3
CNS	EIF2S1 →	-1.120	-1.356	<.001	.001	3	3
PANCREAS	GPBP1L1 →	-0.459	-1.030	.009	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EEF2KMT by Adenosine to inosine editing activity — CNS

Explore this box plot interactively →