mRNA splice site recognition

Across TCGA patient cohorts, RNA activity of the mRNA splice site recognition pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC7A, OLR1, and ACYP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA splice site recognition activity versus CLEC7A in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CLEC7A →	-0.663	-0.225	.005	.003	3	6
GBM	OLR1 →	-1.303	-0.343	<.001	<.001	3	6
GBM	ACYP1 →	+0.660	+0.320	<.001	<.001	3	5
GBM	KIF1C →	-0.582	-0.395	<.001	<.001	3	5
GBM	LMOD1 →	-0.851	-0.375	<.001	<.001	3	5
LSCC	ZNF367 →	+0.901	+0.306	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006376 vs CLEC7A — GBM

Explore this scatter interactively →