mRNA splice site recognition

Across TCGA cell cohorts, RNA activity of the mRNA splice site recognition pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFSWAP, HECTD4, and KIAA0895L, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA splice site recognition activity versus SFSWAP in OESOPHAGUS (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SFSWAP →	+1.092	+0.183	<.001	<.001	3	19
BONE	HECTD4 →	+1.781	+0.134	<.001	<.001	3	18
LARGE_INTESTINE	KIAA0895L →	+1.133	+0.098	<.001	<.001	3	18
BONE	CCNL2 →	+1.539	+0.124	<.001	<.001	3	18
BONE	CDK3 →	+1.439	+0.137	<.001	<.001	3	18
BONE	TAF1C →	+1.203	+0.122	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006376 vs SFSWAP — OESOPHAGUS

Explore this scatter interactively →