Termination of RNA polymerase II transcription

Across TCGA cell cohorts, RNA activity of the Termination of RNA polymerase II transcription pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PELP1, TMEM256, and MED9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PELP1 grouped by Termination of RNA polymerase II transcription-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PELP1 →	-0.830	-0.239	.003	.003	3	7
BLOOD_Leukemia	TMEM256 →	-1.550	-0.265	.003	<.001	3	5
SKIN	MED9 →	-0.574	-0.197	.003	.009	3	5
LUNG_NSCLC_LUSC	CTSC →	+2.391	+0.344	.006	.001	3	4
BLOOD_Leukemia	SLC31A2 →	+1.280	+0.149	.002	.006	3	4
LIVER	GOLGA1 →	+0.498	+0.297	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PELP1 by Termination of RNA polymerase II transcription activity — LIVER

Explore this box plot interactively →