Termination of RNA polymerase II transcription

Across TCGA cell cohorts, RNA activity of the Termination of RNA polymerase II transcription pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX7, STEAP3, and RRAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Termination of RNA polymerase II transcription activity versus SNX7 in OVARY (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SNX7 →	-1.287	-0.603	.007	.006	3	4
LIVER	STEAP3 →	-2.036	-0.347	.006	.004	3	4
LIVER	RRAS →	-2.352	-0.317	.002	.006	3	4
LIVER	BCAR3 →	-2.567	-0.293	.001	.003	3	4
LIVER	SLC27A3 →	+1.472	+0.321	.001	<.001	3	4
LIVER	HPS6 →	-0.633	-0.289	.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006369 vs SNX7 — OVARY

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