Transcription initiation at RNA polymerase II promoter

Across TCGA cell cohorts, RNA activity of the Transcription initiation at RNA polymerase II promoter pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE3C, TDRD7, and NDFIP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE3C grouped by Transcription initiation at RNA polymerase II promoter-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UBE3C →	+0.546	+0.173	.002	.003	3	4
LUNG_NSCLC_LUSC	TDRD7 →	+1.122	+0.197	.001	.001	3	4
BLOOD_Leukemia	NDFIP2 →	+1.866	+0.155	.002	.001	3	4
SKIN	SDCBP →	+1.041	+0.150	.008	.006	3	4
BLOOD_Leukemia	FBXW8 →	-0.928	-0.173	<.001	<.001	3	4
URINARY_TRACT	RPA1 →	-1.013	-0.309	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE3C by Transcription initiation at RNA polymerase II promoter activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →