Transcription initiation at RNA polymerase II promoter

Across TCGA cell cohorts, RNA activity of the Transcription initiation at RNA polymerase II promoter pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALT4, DBR1, and PAQR3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription initiation at RNA polymerase II promoter activity versus B4GALT4 in LUNG_NSCLC_LUAD (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	B4GALT4 →	-1.234	-0.600	.001	.009	3	5
SKIN	DBR1 →	+0.423	+0.827	.002	.001	3	4
LUNG_NSCLC_LUAD	PAQR3 →	+0.653	+0.796	.002	.004	3	4
BREAST	HDX →	+1.072	+0.799	.001	.003	3	4
BREAST	HSF2 →	+0.587	+0.559	.005	.007	3	4
PANCREAS	CHD4 →	+0.977	+1.482	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006367 vs B4GALT4 — LUNG_NSCLC_LUAD

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