Transcription initiation at RNA polymerase I promoter

Across TCGA patient cohorts, RNA activity of the Transcription initiation at RNA polymerase I promoter pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCL11A_S86, TSN, and ILF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription initiation at RNA polymerase I promoter activity versus BCL11A_S86 in LUAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BCL11A_S86 →	+1.305	+0.098	.001	.003	3	7
GBM	TSN →	+0.253	+0.046	<.001	.004	3	7
GBM	ILF2 →	+0.233	+0.052	<.001	<.001	3	7
LSCC	ADNP →	+0.443	+0.063	<.001	<.001	3	7
HNSC	HNRNPLL →	+0.251	+0.077	<.001	<.001	3	7
LUAD	UBA2 →	+0.218	+0.042	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006361 vs BCL11A_S86 — LUAD

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