Transcription initiation at RNA polymerase I promoter

Across TCGA patient cohorts, RNA activity of the Transcription initiation at RNA polymerase I promoter pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRMPD2, SMCR5, and FAM83D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription initiation at RNA polymerase I promoter activity versus FRMPD2 in GBM (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FRMPD2 →	-1.005	-1.039	<.001	<.001	3	4
BRCA	SMCR5 →	+0.061	+0.499	<.001	.002	3	3
COAD	FAM83D →	+0.570	+0.707	.002	.001	3	3
UCEC	POLE2 →	+0.543	+0.555	.001	.001	3	3
UCEC	VRK1 →	+0.763	+0.667	<.001	.007	3	3
UCEC	LSM5 →	+0.577	+0.866	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006361 vs FRMPD2 — GBM

Explore this scatter interactively →