Transcription initiation at RNA polymerase I promoter

Across TCGA cell cohorts, RNA activity of the Transcription initiation at RNA polymerase I promoter pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDNF, ACTR3, and NOP53, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDNF grouped by Transcription initiation at RNA polymerase I promoter-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CDNF →	+0.990	+0.482	.003	.007	3	4
CNS	ACTR3 →	-0.754	-0.253	.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	NOP53 →	+0.838	+0.424	.004	.007	3	3
BLOOD_Leukemia	DCAF7 →	-0.592	-0.295	.001	.004	3	3
BLOOD_Leukemia	ARHGAP11A →	-1.332	-0.247	.005	.007	3	3
BLOOD_Leukemia	RANBP3 →	-0.589	-0.246	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDNF by Transcription initiation at RNA polymerase I promoter activity — URINARY_TRACT

Explore this box plot interactively →