Regulation of transcription by RNA polymerase III

Across TCGA cell cohorts, RNA activity of the Regulation of transcription by RNA polymerase III pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUBP2, CRISPLD2, and WDR53, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUBP2 grouped by Regulation of transcription by RNA polymerase III-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NUBP2 →	-0.482	-0.215	.002	<.001	3	5
PANCREAS	CRISPLD2 →	-1.425	-0.147	<.001	<.001	3	4
SOFT_TISSUE	WDR53 →	-0.527	-0.184	.004	.003	3	4
BLOOD_Leukemia	VKORC1 →	-0.796	-0.218	.001	<.001	3	4
LUNG_SCLC	METTL17 →	-0.798	-0.307	.006	.001	3	4
SKIN	TUBA4A →	-1.567	-0.188	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUBP2 by Regulation of transcription by RNA polymerase III activity — OESOPHAGUS

Explore this box plot interactively →