Regulation of transcription by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Regulation of transcription by RNA polymerase I pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF19, REXO4, and SF3B3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transcription by RNA polymerase I activity versus PRPF19 in LSCC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRPF19 →	+0.331	+0.072	<.001	<.001	3	7
LSCC	REXO4 →	+0.419	+0.051	<.001	<.001	3	6
LSCC	SF3B3 →	+0.295	+0.071	<.001	<.001	3	6
LSCC	SMC1A →	+0.291	+0.059	<.001	<.001	3	6
LSCC	TPR →	+0.240	+0.048	<.001	<.001	3	6
LSCC	BCL11A_S630 →	+1.229	+0.057	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006356 vs PRPF19 — LSCC

Explore this scatter interactively →