Regulation of transcription by RNA polymerase I

Across TCGA cell cohorts, RNA activity of the Regulation of transcription by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GET1, TMCO3, and NEU1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transcription by RNA polymerase I activity versus GET1 in OESOPHAGUS (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GET1 →	-0.978	-0.285	.002	<.001	3	7
LARGE_INTESTINE	TMCO3 →	-0.866	-0.165	<.001	.001	3	6
BLOOD_Myeloma	NEU1 →	-1.507	-0.241	.001	.009	3	6
LUNG_NSCLC_LUSC	CD63 →	-1.191	-0.342	<.001	.001	3	6
LUNG_NSCLC_LUAD	ASAH1 →	-0.769	-0.166	.004	.002	3	6
LUNG_NSCLC_LUAD	SRD5A3 →	-1.009	-0.233	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006356 vs GET1 — OESOPHAGUS

Explore this scatter interactively →