DNA-templated transcription elongation

Across TCGA patient cohorts, RNA activity of the DNA-templated transcription elongation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, VCAN, and FAM83H_S870, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated transcription elongation activity versus RPL5 in OV (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL5 →	-0.187	-0.038	.001	<.001	3	6
CCRCC	VCAN →	+0.838	+0.028	<.001	<.001	3	6
LSCC	FAM83H_S870 →	-1.089	-0.038	<.001	<.001	3	6
GBM	STIM1_S257 →	-0.583	-0.035	.003	<.001	3	6
LSCC	CSNK1A1 →	-0.344	-0.030	<.001	.002	3	6
HNSC	ISYNA1 →	+0.298	+0.056	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006354 vs RPL5 — OV

Explore this scatter interactively →