DNA-templated transcription elongation

Across TCGA cell cohorts, RNA activity of the DNA-templated transcription elongation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB15, S100A13, and STRN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB15 grouped by DNA-templated transcription elongation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RAB15 →	-2.259	-0.219	<.001	.002	3	5
LUNG_SCLC	S100A13 →	+2.224	+0.180	<.001	.003	3	4
BLOOD_Leukemia	STRN →	-0.853	-0.194	<.001	<.001	3	4
BLOOD_Leukemia	AUNIP →	-0.756	-0.156	<.001	.007	3	4
BLOOD_Leukemia	LARP4 →	-1.237	-0.253	<.001	<.001	3	4
BLOOD_Leukemia	SPAST →	-0.779	-0.177	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB15 by DNA-templated transcription elongation activity — BLOOD_Leukemia

Explore this box plot interactively →