DNA-templated transcription termination

Across TCGA patient cohorts, RNA activity of the DNA-templated transcription termination pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR5, BRD9, and ADNP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated transcription termination activity versus WDR5 in GBM (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WDR5 →	+0.348	+0.042	.002	.004	3	7
COAD	BRD9 →	+0.252	+0.034	.001	.001	3	7
LSCC	ADNP →	+0.389	+0.071	<.001	<.001	3	7
LSCC	HCFC1 →	+0.189	+0.069	<.001	<.001	3	7
LSCC	CELF1 →	+0.349	+0.072	<.001	<.001	3	7
GBM	HIRIP3_S125 →	+0.725	+0.039	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006353 vs WDR5 — GBM

Explore this scatter interactively →