DNA-templated transcription termination

Across TCGA patient cohorts, RNA activity of the DNA-templated transcription termination pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, ATM, and ZNF169, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated transcription termination activity versus IRS2 in CCRCC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IRS2 →	+0.558	+0.297	.004	.003	3	3
PDAC	ATM →	+0.253	+0.315	.003	.009	3	3
PDAC	ZNF169 →	+0.279	+0.449	.002	.002	3	3
PDAC	PRRT3-AS1 →	+0.265	+0.287	.009	.003	3	3
PDAC	IFT74 →	+0.293	+0.437	.006	.001	3	3
BRCA	SPATA32 →	+0.235	+0.171	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006353 vs IRS2 — CCRCC

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