DNA-templated transcription termination

Across TCGA cell cohorts, RNA activity of the DNA-templated transcription termination pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFAND1, SMIM11B, and COMT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFAND1 grouped by DNA-templated transcription termination-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZFAND1 →	+0.512	+0.201	.004	.002	3	4
LIVER	SMIM11B →	+0.866	+0.317	.002	.007	3	4
PANCREAS	COMT →	-0.814	-0.231	.002	.006	3	4
BREAST	AIFM1 →	-0.678	-0.135	<.001	<.001	3	4
OVARY	HSD17B10 →	-0.592	-0.140	.006	.009	3	4
STOMACH	CLDN5 →	-0.161	-0.226	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFAND1 by DNA-templated transcription termination activity — SKIN

Explore this box plot interactively →