DNA-templated transcription initiation

Across TCGA patient cohorts, RNA activity of the DNA-templated transcription initiation pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP192, ANKRD26, and EDRF1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated transcription initiation activity versus CEP192 in UVM (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	CEP192 →	+1.472	+0.057	<.001	<.001	3	34
UVM	ANKRD26 →	+1.245	+0.057	<.001	<.001	3	34
UVM	EDRF1 →	+1.257	+0.058	<.001	<.001	3	34
UVM	CPSF6 →	+1.093	+0.056	<.001	<.001	3	34
UVM	ZNF451 →	+1.432	+0.059	<.001	<.001	3	34
UVM	MED23 →	+1.268	+0.052	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006352 vs CEP192 — UVM

Explore this scatter interactively →