DNA-templated transcription initiation

Across TCGA cell cohorts, RNA activity of the DNA-templated transcription initiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP2C, SEC23IP, and ERMP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated transcription initiation activity versus RAP2C in SOFT_TISSUE (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RAP2C →	-0.682	-0.081	.007	.005	3	4
LUNG_SCLC	SEC23IP →	-0.786	-0.135	.001	.008	3	4
BONE	ERMP1 →	-1.835	-0.147	<.001	.006	3	3
BLOOD_Leukemia	DDX39B →	+0.518	+0.107	.003	.002	3	3
BLOOD_Leukemia	RALB →	-1.625	-0.143	.001	<.001	3	3
LUNG_SCLC	PLD1 →	-1.081	-0.139	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006352 vs RAP2C — SOFT_TISSUE

Explore this scatter interactively →