DNA replication-dependent chromatin assembly

Across TCGA cell cohorts, RNA activity of the DNA replication-dependent chromatin assembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELOF1, RIPK1, and CNOT8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELOF1 grouped by DNA replication-dependent chromatin assembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ELOF1 →	-0.536	-0.279	<.001	.003	3	5
LARGE_INTESTINE	RIPK1 →	-0.649	-0.198	.003	.003	3	4
LARGE_INTESTINE	CNOT8 →	-0.694	-0.194	<.001	.005	3	4
LUNG_SCLC	ZNF362 →	-1.248	-0.152	.003	.003	3	4
BLOOD_Lymphoma	MORN4 →	-2.655	-0.309	<.001	.003	3	4
SKIN	CYB5RL →	-0.479	-0.167	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELOF1 by DNA replication-dependent chromatin assembly activity — LIVER

Explore this box plot interactively →