Mitotic recombination

Across TCGA cell cohorts, RNA activity of the Mitotic recombination pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMSB4X, ZCWPW1, and TBC1D14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic recombination activity versus TMSB4X in SKIN (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMSB4X →	-2.982	-1.237	.007	.001	3	5
BLOOD_Leukemia	ZCWPW1 →	-0.757	-0.813	<.001	.002	3	4
BLOOD_Lymphoma	TBC1D14 →	+0.806	+0.668	<.001	.001	3	4
PANCREAS	RFX1 →	+0.591	+0.892	.002	.006	3	4
SOFT_TISSUE	BAHCC1 →	+1.833	+1.604	.007	<.001	3	4
BONE	RENBP →	+2.672	+1.310	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006312 vs TMSB4X — SKIN

Explore this scatter interactively →