Apoptotic DNA fragmentation

Across TCGA patient cohorts, RNA activity of the Apoptotic DNA fragmentation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP11A_S620, TACC1, and RRM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic DNA fragmentation activity versus ARHGAP11A_S620 in PDAC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ARHGAP11A_S620 →	+0.814	+0.081	.008	<.001	3	4
UCEC	TACC1 →	-0.285	-0.047	.003	<.001	3	4
COAD	RRM1 →	+0.356	+0.028	.002	.002	3	4
HNSC	CHD1L →	+0.289	+0.063	.002	<.001	3	4
LUAD	CYLD →	-0.207	-0.038	.001	.002	3	4
HNSC	KIF13A →	-0.321	-0.062	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006309 vs ARHGAP11A_S620 — PDAC

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