Apoptotic DNA fragmentation

Across TCGA patient cohorts, RNA activity of the Apoptotic DNA fragmentation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAV1, IGLV3-16, and IGHV4-61, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic DNA fragmentation activity versus VAV1 in COAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VAV1 →	-0.429	-0.234	.005	<.001	3	3
COAD	IGLV3-16 →	-0.915	-0.152	.004	.009	3	3
COAD	IGHV4-61 →	-1.666	-0.215	.001	.002	3	3
LUAD	MEAF6 →	+0.365	+0.150	<.001	.004	3	3
OV	KCNJ2 →	-0.734	-0.258	<.001	.003	3	3
OV	TREML1 →	-0.514	-0.292	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006309 vs VAV1 — COAD

Explore this scatter interactively →