Apoptotic DNA fragmentation

Across TCGA cell cohorts, RNA activity of the Apoptotic DNA fragmentation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX50, SP1, and RFPL4B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX50 grouped by Apoptotic DNA fragmentation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DDX50 →	+0.682	+1.149	.002	.001	3	4
LIVER	SP1 →	+0.480	+1.208	.009	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RFPL4B →	-0.057	-1.298	.001	<.001	3	3
LIVER	ING2 →	+1.026	+1.146	.002	.006	3	3
LIVER	SPRYD4 →	+0.541	+1.237	.005	<.001	3	3
OVARY	ATP5MPL →	-0.516	-0.864	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX50 by Apoptotic DNA fragmentation activity — LARGE_INTESTINE

Explore this box plot interactively →