Apoptotic DNA fragmentation

Across TCGA cell cohorts, RNA activity of the Apoptotic DNA fragmentation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENDOG, DFFB, and EXOG, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic DNA fragmentation activity versus ENDOG in BLOOD_Leukemia (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ENDOG →	+0.987	+0.065	<.001	<.001	3	13
BLOOD_Lymphoma	DFFB →	+0.756	+0.081	<.001	<.001	3	12
KIDNEY	EXOG →	+0.964	+0.087	.005	.002	3	11
PANCREAS	IFRD2 →	+1.021	+0.089	<.001	.003	3	8
SKIN	RBM28 →	+0.718	+0.053	.007	.008	3	8
SKIN	MRPL34 →	+0.888	+0.071	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006309 vs ENDOG — BLOOD_Leukemia

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