Apoptotic DNA fragmentation

Across TCGA cell cohorts, RNA activity of the Apoptotic DNA fragmentation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK14, SLC2A1, and TPCN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic DNA fragmentation activity versus MAPK14 in KIDNEY (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MAPK14 →	-0.738	-0.245	.005	<.001	3	4
STOMACH	SLC2A1 →	-2.755	-0.341	<.001	.003	3	4
LUNG_SCLC	TPCN2 →	-1.056	-0.249	.002	.002	3	4
SKIN	BRI3 →	+0.857	+0.384	.003	.003	3	4
OESOPHAGUS	COL7A1 →	-3.888	-0.323	<.001	.001	3	4
BLOOD_Lymphoma	TSR2 →	+0.748	+0.352	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006309 vs MAPK14 — KIDNEY

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