DNA catabolic process

Across TCGA patient cohorts, RNA activity of the DNA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RERE_S642, ZBTB21_S422, and RNF20_S525, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA catabolic process activity versus RERE_S642 in HNSC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RERE_S642 →	+0.370	+0.051	<.001	<.001	3	4
BRCA	ZBTB21_S422 →	-0.488	-0.032	.001	.003	3	4
COAD	RNF20_S525 →	+0.639	+0.045	.001	<.001	3	3
PDAC	VRK3_S83 →	+0.692	+0.052	.001	.008	3	3
UCEC	CEP43_S156 →	+0.385	+0.040	<.001	.002	3	3
UCEC	COPG1 →	+0.174	+0.052	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006308 vs RERE_S642 — HNSC

Explore this scatter interactively →