DNA alkylation repair

Across TCGA patient cohorts, RNA activity of the DNA alkylation repair pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MGMT, MGMT_S201, and VWA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA alkylation repair activity versus MGMT in COAD (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MGMT →	+0.603	+0.042	<.001	<.001	3	8
COAD	MGMT_S201 →	+0.519	+0.036	.002	.001	2	8
UCEC	VWA2 →	+0.711	+0.070	.006	.006	3	5
BRCA	NFIA →	+0.416	+0.040	.002	<.001	3	5
CCRCC	SAMSN1_S347 →	-0.511	-0.049	.002	.001	3	4
BRCA	TCOF1_T249 →	-0.629	-0.028	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006307 vs MGMT — COAD

Explore this scatter interactively →