DNA alkylation repair

Across TCGA patient cohorts, RNA activity of the DNA alkylation repair pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KANSL1-AS1, LOXL3, and MAP1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA alkylation repair activity versus KANSL1-AS1 in OV (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KANSL1-AS1 →	+0.658	+0.096	.001	.007	3	3
LUAD	LOXL3 →	-0.324	-0.101	<.001	.009	3	3
GBM	MAP1A →	-0.581	-0.190	.007	.007	3	3
LUAD	MMP17 →	-0.724	-0.128	.004	.007	3	3
LUAD	ZNF812P →	+0.707	+0.163	.006	<.001	3	3
LUAD	MIR6503 →	+0.631	+0.103	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006307 vs KANSL1-AS1 — OV

Explore this scatter interactively →