DNA alkylation repair

Across TCGA patient cohorts, RNA activity of the DNA alkylation repair pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASCC2_T233, SPP1_S234, and DCTPP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA alkylation repair activity versus ASCC2_T233 in BRCA (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASCC2_T233 →	+0.700	+0.162	<.001	.003	2	4
LUAD	SPP1_S234 →	-1.301	-0.151	<.001	<.001	3	3
GBM	DCTPP1 →	+0.390	+0.190	.001	.001	3	3
GBM	ETV6_S439 →	+0.583	+0.254	<.001	<.001	3	3
OV	NCOR1_S992 →	+1.337	+0.203	<.001	<.001	3	3
UCEC	PDLIM7_S260 →	-0.553	-0.217	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006307 vs ASCC2_T233 — BRCA

Explore this scatter interactively →