DNA alkylation repair

Across TCGA cell cohorts, RNA activity of the DNA alkylation repair pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPG, MGMT, and ALKBH3, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MPG grouped by DNA alkylation repair-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MPG →	-0.456	-1.338	.001	.009	3	11
LUNG_SCLC	MGMT →	-0.319	-1.294	.002	.001	3	8
OESOPHAGUS	ALKBH3 →	-0.131	-1.196	.007	.004	2	7
KIDNEY	MROH5 →	-0.389	-1.857	.008	<.001	3	5
STOMACH	CDC25C →	-0.295	-1.363	.002	.004	3	5
KIDNEY	PLRG1 →	-0.296	-0.901	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MPG by DNA alkylation repair activity — OESOPHAGUS

Explore this box plot interactively →