DNA modification

Across TCGA cell cohorts, RNA activity of the DNA modification pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ODF2L, SERTAD1, and POP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ODF2L grouped by DNA modification-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ODF2L →	+1.428	+0.762	.003	.009	3	4
BLOOD_Leukemia	SERTAD1 →	-0.862	-0.749	<.001	.007	3	4
LUNG_NSCLC_LUAD	POP4 →	-0.435	-0.677	.007	.003	3	4
LUNG_NSCLC_LUAD	OPA3 →	-0.455	-0.773	.007	.002	3	4
STOMACH	CEP89 →	-1.183	-1.311	.001	.002	3	4
STOMACH	AP2S1 →	-1.056	-1.405	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ODF2L by DNA modification activity — BREAST

Explore this box plot interactively →