DNA modification

Across TCGA cell cohorts, RNA activity of the DNA modification pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1A1, ZBTB3, and RPUSD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA modification activity versus EEF1A1 in LARGE_INTESTINE (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EEF1A1 →	+0.633	+0.212	.002	.001	3	4
LUNG_SCLC	ZBTB3 →	-0.732	-0.314	<.001	<.001	3	4
BLOOD_Leukemia	RPUSD2 →	-0.288	-0.145	.007	.002	3	4
BLOOD_Myeloma	ZNF169 →	-0.879	-0.215	.002	.005	3	4
STOMACH	SLC35B4 →	-0.854	-0.244	.001	.001	3	4
OVARY	TJP3 →	-1.619	-0.173	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006304 vs EEF1A1 — LARGE_INTESTINE

Explore this scatter interactively →