Double-strand break repair via nonhomologous end joining

Across TCGA patient cohorts, RNA activity of the Double-strand break repair via nonhomologous end joining pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILKAP, HPF1, and EPS8L2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via nonhomologous end joining activity versus ILKAP in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ILKAP →	+0.214	+0.023	<.001	<.001	3	7
LUAD	HPF1 →	+0.149	+0.018	<.001	<.001	3	7
GBM	EPS8L2 →	-0.593	-0.030	<.001	<.001	3	7
UCEC	SMARCD1 →	+0.299	+0.049	.002	.003	3	6
UCEC	NBEAL1 →	-0.268	-0.049	<.001	<.001	3	6
OV	ITPRID2_S759 →	-0.873	-0.035	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006303 vs ILKAP — BRCA

Explore this scatter interactively →