Double-strand break repair via nonhomologous end joining

Across TCGA cell cohorts, RNA activity of the Double-strand break repair via nonhomologous end joining pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM1, KLHL26, and TRIM9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDLIM1 grouped by Double-strand break repair via nonhomologous end joining-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PDLIM1 →	+2.074	+0.168	.002	<.001	2	5
LUNG_NSCLC_LUSC	KLHL26 →	+0.691	+0.152	<.001	.005	3	4
SKIN	TRIM9 →	-1.336	-0.125	.007	.007	3	4
SKIN	FAM72C →	+1.007	+0.145	.002	.003	3	4
KIDNEY	ADCK5 →	+0.685	+0.129	<.001	.008	3	4
CNS	RNF146 →	-0.410	-0.131	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDLIM1 by Double-strand break repair via nonhomologous end joining activity — CNS

Explore this box plot interactively →