Double-strand break repair via nonhomologous end joining

Across TCGA cell cohorts, RNA activity of the Double-strand break repair via nonhomologous end joining pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BICDL1, TMEM18, and RNF216, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via nonhomologous end joining activity versus BICDL1 in URINARY_TRACT (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	BICDL1 →	-2.686	-0.253	.003	.008	3	6
PANCREAS	TMEM18 →	+0.787	+0.226	.002	<.001	3	6
LARGE_INTESTINE	RNF216 →	+0.645	+0.157	.002	.002	3	5
BREAST	RAPGEF2 →	+0.841	+0.118	<.001	.001	3	5
SKIN	PLPPR2 →	+2.074	+0.239	.003	.005	3	5
SOFT_TISSUE	SNX21 →	+1.553	+0.142	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006303 vs BICDL1 — URINARY_TRACT

Explore this scatter interactively →