Postreplication repair

Across TCGA cell cohorts, RNA activity of the Postreplication repair pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL8A, ERMARD, and DNM3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARL8A grouped by Postreplication repair-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ARL8A →	-0.799	-0.224	.006	.002	3	4
SOFT_TISSUE	ERMARD →	+0.738	+0.164	.001	.002	3	4
SOFT_TISSUE	DNM3 →	+2.695	+0.210	.001	<.001	2	5
BLOOD_Myeloma	ZNF428 →	-1.429	-0.274	<.001	.004	3	4
KIDNEY	NCOA1 →	-1.015	-0.249	<.001	<.001	3	4
OESOPHAGUS	UBE2J1 →	-1.125	-0.277	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARL8A by Postreplication repair activity — CNS

Explore this box plot interactively →