Mismatch repair

Across TCGA patient cohorts, RNA activity of the Mismatch repair pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR62, DARS2, and NCAPH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mismatch repair activity versus WDR62 in GBM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WDR62 →	+0.900	+0.780	<.001	.001	3	7
HNSC	DARS2 →	+0.430	+0.255	.003	<.001	3	6
GBM	NCAPH →	+1.094	+1.092	<.001	<.001	3	6
UCEC	ESPL1 →	+1.147	+1.065	<.001	<.001	3	6
GBM	NCAPG2 →	+0.840	+0.994	<.001	<.001	3	6
GBM	CDC25C →	+1.134	+1.114	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006298 vs WDR62 — GBM

Explore this scatter interactively →