Mismatch repair

Across TCGA patient cohorts, RNA activity of the Mismatch repair pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX41, SMC2, and FANCD2_S1435, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mismatch repair activity versus DDX41 in GBM (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DDX41 →	+0.233	+1.043	<.001	<.001	2	7
GBM	SMC2 →	+0.825	+0.903	<.001	<.001	3	6
BRCA	FANCD2_S1435 →	+1.117	+0.530	<.001	<.001	3	6
GBM	MED23 →	+0.299	+1.068	<.001	<.001	3	6
GBM	RFC2 →	+0.463	+1.012	<.001	<.001	2	6
GBM	RFC5 →	+0.512	+0.961	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006298 vs DDX41 — GBM

Explore this scatter interactively →