Mismatch repair

Across TCGA cell cohorts, RNA activity of the Mismatch repair pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF10, CTCF, and SCAF4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mismatch repair activity versus SRSF10 in BLOOD_Leukemia (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SRSF10 →	+0.679	+0.457	.002	.009	3	7
BLOOD_Leukemia	CTCF →	+0.832	+0.399	<.001	<.001	3	7
LIVER	SCAF4 →	+0.811	+1.209	.001	.002	3	7
LUNG_NSCLC_LUSC	ZNF821 →	+1.305	+1.679	.004	<.001	3	6
SOFT_TISSUE	KDM2B →	+1.013	+0.319	.003	<.001	2	7
URINARY_TRACT	ST13 →	+0.514	+1.222	.007	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006298 vs SRSF10 — BLOOD_Leukemia

Explore this scatter interactively →